You’re in Pain and You want Relief Naturally

You’re in pain, and ibuprofen just won’t cut it. Nonsteroidal anti-inflammatory drugs, or NSAIDs, don’t agree with your stomach, and you’re wary of stronger meds.

Fortunately, you have alternatives — natural ones. From herbs that attack inflammation to techniques that leverage the brain’s remarkable healing powers, nature offers many treatments for conditions such as arthritis, fibromyalgia, and even muscle strains.

Here are eight natural remedies that may enhance or replace conventional antidotes, and leave you happier, healthier, and pain free.

Capsaicin: For Arthritis, Shingles, or Neuropathy

What the science says: An active component of chile pepper, capsaicin temporarily desensitizes pain-prone skin nerve receptors called C-fibers; soreness is diminished for 3 to 5 weeks while they regain sensation. Nearly 40 percent of arthritis patients reduced their pain by half after using a topical capsaicin cream for a month, and 60 percent of neuropathy patients achieved the same after 2 months, according to a University of Oxford study. Patients at the New England Center for Headache decreased their migraine and cluster headache intensity after applying capsaicin cream inside their nostrils.

How to try it: Capsaicin ointments and creams are sold in pharmacies and health stores. For arthritis or neuropathy, try 0.025 percent or 0.075 percent capsaicin cream one to four times daily; best results can take up to 2 weeks, says Philip Gregory, PharmD, a professor at Creighton University and editor of the Natural Medicines Comprehensive Database. But research on capsaicin and headaches remains limited — and don’t expect stronger versions anytime soon: “Current formulations are better suited for more acute problems, like a sore muscle or an arthritis flare-up, than everyday pain and stiffness,” Gregory says.

InflaThera or Zyflamend: For Arthritis

What the science says: Both supplement brands contain ginger, turmeric, and holy basil, all of which have anti-inflammatory properties. Turmeric (a curry ingredient) may be the best: A component, curcumin, eases inflammatory conditions like rheumatoid arthritis and psoriasis, according to the Methodist Research Institute in Indianapolis. Researchers are now testing Zyflamend in RA patients, but some experts are already sold: “Each herb has its own scientific database of evidence,” says James Dillard, MD, author of “The Chronic Pain Solution.”

How to try it: ProThera, InflaThera’s maker, will only sell to health care professionals, so your doctor has to order it for you; that said, it’s reportedly stronger (and slightly cheaper) than Zyflamend. InflaThera’s suggested dosage is twice daily with food. For the more readily accessible Zyflamend, take one capsule two or three times daily, but avoid it near bedtime — each pill contains 10 mg of caffeine (another version, Zyflamend PM, is reportedly less stimulating). Save money and try curcumin to start: Taking 500 mg four times daily, along with fish oil and a diet low in animal fat, can ease arthritis, says Jane Guiltinan, ND, immediate past president of the American Association of Naturopathic Physicians.

Arnica: For Acute Injury or Post Surgery Swelling

What the science says: This herb comes from a European flower; although its healing mechanism is still unknown, it does have natural anti-inflammatory properties. Taking oral homeopathic arnica after a tonsillectomy decreases pain, say British researchers, and German doctors found that it reduces surgery-related knee swelling.

How to try it: Use homeopathic arnica as an adjunct to ice, herbs, or conventional pain meds, suggests Guiltinan. Rub arnica ointment on bruises or strained muscles, or take it in the form of three lactose pellets under the tongue up to six times per day. Boiron is among the most reputable arnica manufacturers.

Aquamin: For Osteoarthritis

What the science says: This red seaweed supplement is rich in calcium and magnesium. A preliminary clinical study showed that the ingredients may reduce joint inflammation or even help build bone, says David O’Leary of Marigot, Aquamin’s Irish manufacturer. In a study of 70 volunteers published in Nutrition Journal, Aquamin users reduced arthritis pain by 20 percent in a month, and had less stiffness than patients taking a placebo.

How to try it: Marigot recommends 2,400 mg a day (two capsules) of Aquamin in tablet form, sold domestically in products such as Aquamin Sea Minerals and Cal-Sea-Um. A 60-pill jar of Swanson Vegetarian Aquamin Sea Minerals costs about $6 at swansonvitamins.com.

SAM-e (S adenosylmethionine): For Osteoarthritis

What the science says: SAM-e is made from a naturally occurring amino acid and sold as capsules. Doctors aren’t entirely sure why it tamps down pain, but it reduces inflammation and may increase the feel-good brain chemicals serotonin and dopamine.

Studies by the University of Maryland School of Nursing and the University of California, Irvine, showed that SAM-e was as effective as some NSAIDs in easing osteoarthritis aches; the California researchers found that SAM-e quashed pain by 50 percent after 2 months, though it took a few weeks to kick in. SAM-e produced no cardiovascular risks and fewer stomach problems than the conventional meds.

How to try it: Costco and CVS both carry it; a month’s supply costs $30 to $60. Guiltinan prescribes 400 to 1,600 mg daily, often with turmeric or fish oil. SAM-e can interact with other meds, especially MAO-inhibitor antidepressants, so it’s vital to talk with your doctor before taking it (and avoid SAM-e entirely if you have bipolar disorder).

Also, inspect the packaging before buying, advises Gregory: Make sure the product carries a USP or GMP quality seal, contains a stabilizing salt, has a far-off expiration date, and comes in foil blister packs — SAM-e can degrade rapidly in direct light.

Fish oil: For Joint Pain from Arthritis or Autoimmune Disorders

What the science says: Digested fish oil breaks down into hormonelike chemicals called prostaglandins, which reduce inflammation. In one study, about 40 percent of rheumatoid arthritis patients who took cod-liver oil every day were able to cut their NSAID use by more than a third, Scottish scientists recently reported. People with neck and back pain have fared even better: After about 10 weeks, nearly two-thirds were able to stop taking NSAIDs altogether in a University of Pittsburgh study.

How to try it: Taking 1,000 mg is proven to help your heart, but you should up the dose for pain. For osteoarthritis, try 2,000 to 4,000 mg daily; for rheumatoid arthritis and autoimmune diseases associated with joint pain (such as lupus), consider a much higher dose of upwards of 8,000 mg daily — but ask your doctor about such a large amount first, says Tanya Edwards, MD, medical director at the Cleveland Clinic’s Center for Integrative Medicine. (The same rule applies if you take BP or heart meds, as omega-3s can thin the blood.) Read the nutrition label carefully: The dosage refers to the amount of omega-3s in a capsule, not other ingredients. Nordic Naturals (nordicnaturals.com) and Carlson (carlsonlabs.com) are both reputable brands.

Methylsulfonyl-Methane (MSM): For Osteoarthritis

What the science says: MSM is derived from sulfur and may prevent joint and cartilage degeneration, say University of California, San Diego, scientists. People with osteoarthritis of the knee who took MSM had 25 percent less pain and 30 percent better physical function at the end of a 3-month trial at Southwest College of Naturopathic Medicine and Health Sciences. Indian researchers also found that MSM worked better when combined with glucosamine.

How to try it: Start with 1.5 to 3 g once daily and increase to 3 g twice daily for more severe pain, suggests Leslie Axelrod, ND, a professor of clinical sciences at Southwest. Patients in the Indian trial improved on dosages as low as 500 mg three times daily. Vendors of OptiMSM, the brand tested in Axelrod’s trial, can be found at optimsm.com.

Counting Out Loud: For Brief “Needle Stick” Pain

What the science says: Patients who counted backward from 100 out loud during an injection experienced and recalled less pain, according to a recent Japanese study. None of the 46 patients who counted complained afterward, and only one of them could remember pain from the injection at all (among the 46 who didn’t count, 19 said the injection hurt and 10 recalled what it felt like). Recitation might work by distracting the brain from processing the sensation, says study author Tomoko Higashi, MD, of Yokohama City University Medical Center in Kanagawa, Japan. The trick is probably only useful for short or acute periods, she says, adding: “The degree of pain reduction really depends on how well patients concentrate on counting.”

Stem Cell Blindbess Study Results

By ALICIA CHANG, AP Science Writer Alicia Chang, Ap Science Writer   – Wed Jun 23, 7:29 pm ET

LOS ANGELES – Dozens of people who were blinded or otherwise suffered severe eye damage when they were splashed with caustic chemicals had their sight restored with transplants of their own stem cells — a stunning success for the burgeoning cell-therapy field, Italian researchers reported Wednesday.

The treatment worked completely in 82 of 107 eyes and partially in 14 others, with benefits lasting up to a decade so far. One man whose eyes were severely damaged more than 60 years ago now has near-normal vision.

“This is a roaring success,” said ophthalmologist Dr. Ivan Schwab of the University of California, Davis, who had no role in the study — the longest and largest of its kind.

Stem cell transplants offer hope to the thousands of people worldwide every year who suffer chemical burns on their corneas from heavy-duty cleansers or other substances at work or at home.

The approach would not help people with damage to the optic nerve or macular degeneration, which involves the retina. Nor would it work in people who are completely blind in both eyes, because doctors need at least some healthy tissue that they can transplant.

In the study, published online by the New England Journal of Medicine, researchers took a small number of stem cells from a patient’s healthy eye, multiplied them in the lab and placed them into the burned eye, where they were able to grow new corneal tissue to replace what had been damaged. Since the stem cells are from their own bodies, the patients do not need to take anti-rejection drugs.

Adult stem cells have been used for decades to cure blood cancers such as leukemia and diseases like sickle cell anemia. But fixing a problem like damaged eyes is a relatively new use. Researchers have been studying cell therapy for a host of other diseases, including diabetes and heart failure, with limited success.

Adult stem cells, which are found around the body, are different from embryonic stem cells, which come from human embryos and have stirred ethical concerns because removing the cells requires destroying the embryos.

Currently, people with eye burns can get an artificial cornea, a procedure that carries such complications as infection and glaucoma, or they can receive a transplant using stem cells from a cadaver, but that requires taking drugs to prevent rejection.

The Italian study involved 106 patients treated between 1998 and 2007. Most had extensive damage in one eye, and some had such limited vision that they could only sense light, count fingers or perceive hand motions. Many had been blind for years and had had unsuccessful operations to restore their vision.

The cells were taken from the limbus, the rim around the cornea, the clear window that covers the colored part of the eye. In a normal eye, stem cells in the limbus are like factories, churning out new cells to replace dead corneal cells. When an injury kills off the stem cells, scar tissue forms over the cornea, clouding vision and causing blindness.

In the Italian study, the doctors removed scar tissue over the cornea and glued the laboratory-grown stem cells over the injured eye. In cases where both eyes were damaged by burns, cells were taken from an unaffected part of the limbus.

Researchers followed the patients for an average of three years and some as long as a decade. More than three-quarters regained sight after the transplant. An additional 13 percent were considered a partial success. Though their vision improved, they still had some cloudiness in the cornea.

Patients with superficial damage were able to see within one to two months. Those with more extensive injuries took several months longer.

“They were incredibly happy. Some said it was a miracle,” said one of the study leaders, Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine in Italy. “It was not a miracle. It was simply a technique.”

The study was partly funded by the Italian government.

Researchers in the United States have been testing a different way to use self-supplied stem cells, but that work is preliminary.

One of the successful transplants in the Italian study involved a man who had severe damage in both eyes as a result of a chemical burn in 1948. Doctors grafted stem cells from a small section of his left eye to both eyes. His vision is now close to normal.

In 2008, there were 2,850 work-related chemical burns to the eyes in the United States, according to the Bureau of Labor Statistics.

Schwab of UC Davis said stem cell transplants would not help those blinded by burns in both eyes because doctors need stem cells to do the procedure.

“I don’t want to give the false hope that this will answer their prayers,” he said.

Dr. Sophie Deng, a cornea expert at the UCLA’s Jules Stein Eye Institute, said the biggest advantage was that the Italian doctors were able to expand the number of stem cells in the lab. This technique is less invasive than taking a large tissue sample from the eye and lowers the chance of an eye injury.

“The key is whether you can find a good stem cell population and expand it,” she said.
___
Online:

New England Journal: http://www.nejm.org

Twinlab Corp., which has 320 workers in American Fork, was accused in a lawsuit filed Tuesday by Mateel Environmental Justice Foundation and two environmentalists of misleading consumers about the levels of polychlorinated biphenyls, or PCBs, in two of their fish oil supplements, Twinlab’s Norwegian Cod Liver Oil and Emulsified Norwegian Cod Liver Oil.

Even though these two Twinlab supplements claim they are “PCB and heavy metal free,” they allegedly contain PCBs above the “safe harbor” limits set for human consumption under California’s Proposition 65, which requires consumers to be warned about exposure to toxic chemicals, according to the San Francisco Superior Court suit.

The two Twinlab supplements are sold online at www.twinlab.com, said Justin Boone, spokesman for the company. But he wasn’t able to specify on Wednesday which retailers in Utah carry the two products. The company’s Web site shows its supplements are available through retailers including Wal-Mart, Target, Sam’s Club, Whole Foods, Wild Oats, Walgreens, Vitamin World, Vitamin Shoppe, Rite Aid and GNC.

In addition to Twinlab, the suit names seven retailers and manufacturers of fish oil, shark oil, fish liver oil and shark liver oil supplements. They include: CVS Pharmacy Inc.; General Nutrition Corp.; Now Health Group Inc.; Omega Protein Inc.; Pharmavite LLC (which sells fish oils under the Nature Made brand); Rite Aid Corp.; and Solgar Inc.

What makes the defendants’ marketing claims egregious is that the 10 fish oil supplements, which are recommended to pregnant women and children for their health benefits, are marketed as being already treated for PCB contamination when the problem still exists, said Benson Chiles, an environmentalist that brought the lawsuit.

Christopher Manthey, another plaintiff, said he and Chiles found in their investigation that the supplements industry “seems very aware that fish oils can be high in PCBs.”

“That’s why many of them say their supplements have been ‘treated’ to remove or reduce PCBs,” he said. “But since they don’t say how much PCB contamination is still left, even consumers who choose ‘treated’ supplements can’t know what PCB levels they’re swallowing along with their daily Omega-3.”

Twinlab, in a statement Wednesday, said it cannot comment on the validity or accuracy of the plaintiffs’ test results, but said its supplements meet stringent government standards and are “molecularly distilled and tested for purity.”

Greg Grochoski, Twinlab’s chief science officer, notes that among the 10 supplements tested, its products were reported as having some of the lowest levels of impurities.

The company also said it has been working with Mateel for several months to develop scientifically valid standards for impurities that can be found in fish oils. It said it uses fish oil suppliers that adhere to industry safety standards.

“This lawsuit is about plaintiffs seeking additional standards under California’s Prop. 65, a consumer disclosure law,” the Twinlab statement said.

David Roe, the plaintiffs’ attorney, said they are seeking civil penalties of up to $2,500 a day for each violation of the California Health and Safety Code.

“The amount of the penalty will depend on what their supplements sales are since Aug. 6, 2009 when we notified the California office of the Attorney General of this problem, and will continue every day until the PCBs are taken out of the products, or until warnings are given,” he said.

“We’re hoping that the suit will stimulate the industry as a whole to get PCBs out of fish oils,” Roe said.

The brand name supplements named in the lawsuit include:

1. Nature Made Cod Liver Oil

2. Nature Made Odorless Fish Oil

3. TwinLab Norwegian Cod Liver Oil

4. TwinLab Emulsified Norwegian Cod Liver Oil

5. Now Foods Shark Liver Oil

6. Now Foods Double Strength Cod Liver Oil

7. Now Foods Salmon Oil

8. Solgar 100% Pure Norwegian Shark Liver Oil Complex

9. Solgar Norwegian Cod Liver Oil

10. GNC Liquid Norwegian Cod Liver Oil

Source: fishoilsafety.com

More information is available at www.fishoilsafety.com.

Soft drinks are hard on your health

Soft drinks contain little to no vitamins or other essential nutrients. However, it is what they do contain that is the problem: caffeine, carbonation, simple sugars — or worse, sugar substitutes — and often food additives such as artificial coloring, flavoring, and preservatives.

A lot of research has found that consumption of soft drinks in high quantity, especially by children, is responsible for many health problems that include tooth decay, nutritional depletion, obesity, type-2 diabetes, and heart disease.

Why the sugar in soft drinks isn’t so sweet

Most soft drinks contain a high amount of simple sugars. The USDA recommendation of sugar consumption for a 2,000-calorie diet is a daily allotment of 10 teaspoons of added sugars. Many soft drinks contain more than this amount!

Just why is too much sugar so unhealthy? Well, to start, let’s talk about what happens to you as sugar enters your body. When you drink sodas that are packed with simple sugars, the pancreas is called upon to produce and release insulin, a hormone that empties the sugar in your blood stream into all the tissues and cells for usage. The result of overindulging in simple sugar is raised insulin levels. Raised blood insulin levels beyond the norm can lead to depression of the immune system, which in turn weakens your ability to fight disease.

Something else to consider is that most of the excess sugar ends up being stored as fat in your body, which results in weight gain and elevates risk for heart disease and cancer. One study found that when subjects were given refined sugar, their white blood cell count decreased significantly for several hours afterwards. Another study discovered that rats fed a high-sugar diet had a substantially elevated rate of breast cancer when compared to rats on a regular diet.

The health effects of diet soda

You may come to the conclusion that diet or sugar-free soda is a better choice. However, one study discovered that drinking one or more soft drinks a day — and it didn’t matter whether it was diet or regular — led to a 30% greater chance of weight gain around the belly.

Diet soda is filled with artificial sweeteners such as aspartame, sucralose, or saccharin. These artificial sweeteners pose a threat to your health. Saccharin, for instance, has been found to be carcinogenic, and studies have found that it produced bladder cancer in rats.

Aspartame, commonly known as nutrasweet, is a chemical that stimulates the brain to think the food is sweet. It breaks down into acpartic acid, phenylalanine, and methanol at a temperature of 86 degrees. (Remember, your stomach is somewhere around 98 degrees.) An article put out by the University of Texas found that aspartame has been linked to obesity. The process of stimulating the brain causes more cravings for sweets and leads to carbohydrate loading.

Carbonation depletes calcium

Beverages with bubbles contain phosphoric acid, which can severely deplete the blood calcium levels; calcium is a key component of the bone matrix. With less concentration of calcium over a long time, it can lower deposition rates so that bone mass and density suffer. This means that drinking sodas and carbonated water increases your risk of osteoporosis.

Add in the caffeine usually present in soft drinks, and you are in for even more trouble. Caffeine can deplete the body’s calcium, in addition to stimulating your central nervous system and contributing to stress, a racing mind, and insomnia.

Skip the soda and go for:

• Fresh water

Water is a vital beverage for good health. Each and every cell needs water to perform its essential functions. Since studies show that tap water is filled with contaminants, antibiotics, and a number of other unhealthy substances, consider investing in a quality carbon-based filter for your tap water. To find out more about a high-performance filtration system, click here.

On the go? Try using a stainless steel thermos or glass bottle, filled with filtered water. Enhance the flavor of your water with a refreshing infusion of basil, mint leaves, and a drop of honey.

• Fruit Juice

If you are a juice drinker, try watering down your juice to cut back on the sugar content. Buy a jar of organic 100% juice, especially cranberry, acai, pomegranate, and then dilute three parts filtered water to one part juice. You will get a subtle sweet taste and the benefit of antioxidants. After a couple of weeks, you will no longer miss the sweetness of sugary concentrated juices.

• Tea

Tea gently lifts your energy and has numerous health benefits. Black, green, white, and oolong teas all contain antioxidant polyphenols. In fact, tea ranks as high or higher than many fruits and vegetables on the ORAC scale, the score that measures antioxidant potential of plant-based foods.

Herbal tea does not have the same antioxidant properties, though it is still a great beverage choice with other health benefits, such as inducing calming and relaxing effects.

If tea doesn’t satisfy your sweet tooth, try adding cinnamon or a little honey, which has important health benefits that refined sugar lacks. For a selection of healthy teas that promote total body wellness, click here. Drink up!

I hope you find the ways and means to avoid soft drinks. I invite you to visit often and share your own personal health and longevity tips with me.

May you live long, live strong, and live happy!

–Dr. Mao

Source: Yahoo Health

This story released by the Associated Press on Friday Sept. 25, 2009

Can you trust the Government to provide you with clean, safe, drinking water?

CUTLER, Calif. – Over the last decade, the drinking water at thousands of schools across the country has been found to contain unsafe levels of lead, pesticides and dozens of other toxins.

An Associated Press investigation found that contaminants have surfaced at public and private schools in all 50 states — in small towns and inner cities alike.

But the problem has gone largely unmonitored by the federal government, even as the number of water safety violations has multiplied.

“It’s an outrage,” said Marc Edwards, an engineer at Virginia Tech who has been honored for his work on water quality. “If a landlord doesn’t tell a tenant about lead paint in an apartment, he can go to jail. But we have no system to make people follow the rules to keep school children safe?”

The contamination is most apparent at schools with wells, which represent 8 to 11 percent of the nation’s schools. Roughly one of every five schools with its own water supply violated the Safe Drinking Water Act in the past decade, according to data from the Environmental Protection Agency analyzed by the AP.

In California’s farm belt, wells at some schools are so tainted with pesticides that students have taken to stuffing their backpacks with bottled water for fear of getting sick from the drinking fountain.

Experts and children’s advocates complain that responsibility for drinking water is spread among too many local, state and federal agencies, and that risks are going unreported. Finding a solution, they say, would require a costly new national strategy for monitoring water in schools.

Schools with unsafe water represent only a small percentage of the nation’s 132,500 schools. And the EPA says the number of violations spiked over the last decade largely because the government has gradually adopted stricter standards for contaminants such as arsenic and some disinfectants.

Many of the same toxins could also be found in water at homes, offices and businesses. But the contaminants are especially dangerous to children, who drink more water per pound than adults and are more vulnerable to the effects of many hazardous substances.

“There’s a different risk for kids,” said Cynthia Dougherty, head of the EPA’s Office of Groundwater and Drinking Water.

Still, the EPA does not have the authority to require testing for all schools and can only provide guidance on environmental practices.

In recent years, students at a Minnesota elementary school fell ill after drinking tainted water. A young girl in Seattle got sick, too.

The AP analyzed a database showing federal drinking water violations from 1998 to 2008 in schools with their own water supplies. The findings:

• Water in about 100 school districts and 2,250 schools breached federal safety standards.

• Those schools and districts racked up more than 5,550 separate violations. In 2008, the EPA recorded 577 violations, up from 59 in 1998 — an increase that officials attribute mainly to tougher rules.

• California, which has the most schools of any state, also recorded the most violations with 612, followed by Ohio (451), Maine (417), Connecticut (318) and Indiana (289).

• Nearly half the violators in California were repeat offenders. One elementary school in Tulare County, in the farm country of the Central Valley, broke safe-water laws 20 times.

• The most frequently cited contaminant was coliform bacteria, followed by lead and copper, arsenic and nitrates.

The AP analysis has “clearly identified the tip of an iceberg,” said Gina Solomon, a San Francisco physician who serves on an EPA drinking water advisory board. “This tells me there is a widespread problem that needs to be fixed because there are ongoing water quality problems in small and large utilities, as well.”

Schools with wells are required to test their water and report any problems to the state, which is supposed to send all violations to the federal government.

But EPA officials acknowledge the agency’s database of violations is plagued with errors and omissions. And the agency does not specifically monitor incoming state data on school water quality.

Critics say those practices prevent the government from reliably identifying the worst offenders — and carrying out enforcement.

Scientists say the testing requirements fail to detect dangerous toxins such as lead, which can wreak havoc on major organs and may retard children’s learning abilities.

“There is just no excuse for this. Period,” said California Sen. Barbara Boxer, Democratic chairwoman of the Senate Committee on Environment and Public Works. “We want to make sure that we fix this problem in a way that it will never happen again, and we can ensure parents that their children will be safe.”

The problem goes beyond schools that use wells. Schools that draw water from public utilities showed contamination, too, especially older buildings where lead can concentrate at higher levels than in most homes.

In schools with lead-soldered pipes, the metal sometimes flakes off into drinking water. Lead levels can also build up as water sits stagnant over weekends and holidays.

Schools that get water from local utilities are not required to test for toxins because the EPA already regulates water providers. That means there is no way to ensure detection of contaminants caused by schools’ own plumbing.

But voluntary tests in Washington, Baltimore, Philadelphia, Seattle and Los Angeles have found dangerous levels of lead in recent years. And experts warn the real risk to schoolchildren is going unreported.

“I really suspect the level of exposure to lead and other metals at schools is underestimated,” said Michael Schock, a corrosion expert with the EPA in Cincinnati. “You just don’t know what is going on in the places you don’t sample.”

Since 2004, the agency has been asking states to increase lead monitoring. As of 2006, a survey by the Centers for Disease Control and Prevention found nearly half of all schools nationwide do not test their water for lead.

Because contaminant levels in water can vary from drinking fountain to drinking fountain, and different children drink different amounts of water, epidemiologists often have trouble measuring the potential threats to children’s health.

But children have suffered health problems attributed to school water:

• In 2001, 28 children at a Worthington, Minn., elementary school experienced severe stomach aches and nausea after drinking water tainted with lead and copper, the result of a poorly installed treatment system.

• In Seattle several years ago, a 6-year-old girl suffered stomach aches and became disoriented and easily exhausted. The girl’s mother asked her daughter’s school to test its water, and also tested a strand of her daughter’s hair. Tests showed high levels of copper and lead, which figured into state health officials’ decision to phase-in rules requiring schools to test their water for both contaminants.

Many school officials say buying bottled water is less expensive than fixing old pipes. Baltimore, for instance, has spent more than $2.5 million on bottled water over the last six years.

After wrestling with unsafe levels of arsenic for almost two years, administrators in Sterling, Ohio, southeast of Cincinnati, finally bought water coolers for elementary school students last fall. Now they plan to move students to a new building.

In California, the Department of Public Health has given out more than $4 million in recent years to help districts overhaul their water systems.

But school administrators in the farmworker town of Cutler cannot fix chronic water problems at Lovell High School because funding is frozen due to the state’s budget crisis.

Signs posted above the kitchen sink warn students not to drink from the tap because the water is tainted with nitrates, a potential carcinogen, and DBCP, a pesticide scientists say may cause male sterility.

As gym class ended one morning, thirsty basketball players crowded around a five-gallon cooler, the only safe place to get a drink on campus.

“The teachers always remind us to go to the classroom and get a cup of water from the cooler,” said sophomore Israel Aguila. “But the bathroom sinks still work, so sometimes you kind of forget you can’t drink out of them.”

* By Devlin Barrett, Associated Press Writer
* On Wednesday September 2, 2009, 2:57 pm EDT

WASHINGTON (AP) — Pfizer Inc., the world’s largest drug maker, will pay a record $2.3 billion civil and criminal penalty over unlawful prescription drug promotions.

Announcing the settlement Wednesday, the Justice Department said that it included the largest criminal fine in U.S. history — $1.2 billion. The agreement also included a criminal forfeiture of $105 million.

Authorities called Pfizer a repeat offender, noting it is the fourth such settlement of government charges in the last decade. They said the government will monitor the company’s conduct for the next five years to rein in the abuses.

To promote the drugs, authorities said Pfizer invited doctors to consultant meetings at resort locations, paying their expenses and providing perks.

“They were entertained with golf, massages, and other activities,” said Mike Loucks, the U.S. attorney in Massachusetts.

Loucks said that even as Pfizer was negotiating deals on past misconduct, they were continuing to violate the very same laws with other drugs.

Six corporate whisteblowers who first brought the misconduct to light will share $102 million of the settlement money.

FBI Assistant Director Kevin Perkins praised the whistleblowers who decided to “speak out against a corporate giant that was blatantly violating the law and misleading the public through false marketing claims.”

Associate Attorney General Thomas Perelli said the settlement illustrates ways the department “can help the American public at a time when budgets are tight and health care costs are rising.”

The overall settlement is the largest ever paid by a drug company for alleged violations of federal drug rules.

The government said the company promoted four prescription drugs, including the pain killer Bextra, as treatments for medical conditions different than those the drugs had been approved for by federal regulators.

Use of drugs for so-called “off-label” medical conditions is not uncommon, but drug manufacturers are prohibited from marketing drugs for uses that have not been approved by the Food and Drug Administration.

Bextra, one of a class of painkillers known as Cox-2 inhibitors, was pulled from the U.S. market in 2005 amid mounting evidence it raised the risk of heart attack, stroke and death.

A Pfizer subsidiary, Pharmacia and Upjohn Inc., which was acquired in 2003, has entered an agreement to plead guilty to one count of felony misbranding. The criminal case applied only to Bextra.

The $1 billion in civil penalties was related to Bextra and a number of other medicines. A portion of the civil penalty will be distributed to 49 states and the District of Columbia, according to agreements with each state’s Medicaid program.

“These agreements bring final closure to significant legal matters and help to enhance our focus on what we do best — discovering, developing and delivering innovative medicines to treat patients dealing with some of the world’s most debilitating diseases,” said Amy W. Schulman, senior vice president and general counsel of Pfizer.

Justice officials discussed details of the deal at a news conference with FBI, federal prosecutors, and Health and Human Services Department officials.

In financial filings in January, the company had indicated that it would pay $2.3 billion over allegations it had marketed the pain reliever Bextra and possibly other drugs for medical conditions different than their approved use. The civil settlement announced Wednesday also covered Pfizer’s promotions of three other drugs: blockbuster nerve pain and epilepsy treatment Lyrica, schizophrenia medicine Geodon, antibiotic Zyvox and nine other medicines. Pfizer said the agreement with the Justice Department resolves the investigation into promotion of all those drugs, plus several related whistleblower lawsuits.

Under terms of the settlement, Pfizer must pay $1 billion to compensate Medicaid, Medicare, and other federal health care programs. Some of that money will be shared among the states: New York, for example, will receive $66 million, according to the state’s attorney general, Andrew Cuomo.

“Pfizer ripped off New Yorkers and taxpayers across the country to pad its bottom line,” Cuomo said. “Pfizer’s corrupt practices went so far as sending physicians on exotic junkets as well as wining and dining health care professionals to persuade them to prescribe the company’s drugs for patients in taxpayer-funded programs.”

Pfizer spokesman Chris Loder confirmed Wednesday that the $2.3 billion charge to the company’s earnings had been taken in the fourth quarter of 2008.

“No additional charge to the company’s earnings will be recorded in connection with this settlement,” he said.

In her statement, Schulman said: “We regret certain actions taken in the past, but are proud of the action we’ve taken to strengthen our internal controls and pioneer new procedures so that we not only comply with state and federal laws, but also meet the high standards that patients, physicians and the public expect from a leading worldwide company dedicated to healing and better health.”

“Corporate integrity is an absolute priority for Pfizer,” she said, “and we will continue to take appropriate actions to further enhance our compliance practices and strengthen public trust in our company.”

When Pfizer originally disclosed the settlement figure, it also announced plans to acquire rival Wyeth for $68 billion. That deal, which would bolster Pfizer’s position as the world’s top drug maker by revenue, is expected to close before year’s end.

Shares of Pfizer dropped 14 cents to $16.24 in midday trading.

AP Business Writer Linda A. Johnson in Trenton, N.J. contributed to this report.

Say it isn’t so! A recent study out of the University of Carolina at Chapel Hill cites what animal studies have hinted at for years: MSG (aka monosodium glutamate) could be a factor in weight gain.

The study focused on 750 Chinese men and women, ages 40-59, living in 3 rural villages in north and south China. Most of the study subjects prepared their meals at home without commercially processed foods and roughly 82 percent used MSG. Those participants who used the highest amounts of MSG had nearly 3 times the incidence of overweight as those who did not use MSG, even when physical activity, total caloric intake, and other possible explanations for body mass differences were accounted for. The positive correlation between MSG and higher weight confirmed what animal studies have been suggesting for years.

Maybe you’re wondering what monosodium glutamate is exactly, and what you can do to avoid it in your diet. MSG is a flavor enhancer in foods—some believe it may even provide a fifth basic taste sensation (in addition to sweet, sour, salt, and bitter), what the Japanese call “umami” (roughly translated as “tastiness”). MSG is considered an “excitotoxin,” since its action in the body is to excite neurotransmitters (important brain chemicals), causing nerve cells to discharge and also exciting nerves related to taste. Perhaps this ability to excite these nerves is a factor in an association between increased MSG usage and weight gain.

How prevalent is MSG in the U.S. diet? Americans consumed about 1 million pounds of MSG in 1950, and today that number has increased by a factor of 300!

The Food and Drug Administration (FDA) describes MSG as “naturally occurring,” and has it on the GRAS (“generally regarded as safe”) list. However, not only could MSG be causing us to gain weight, but some studies also reveal that as many as 25 to 30 percent of Americans have adverse reactions to it (e.g., palpitations and migraine headaches), and as many as 30 percent are extra sensitive to it if they consume more than 5 grams at one sitting.

OK, if you’re an MSG user who could stand to lose a little weight (or know someone who is), what should you do?

Unfortunately, eliminating MSG from the diet is much easier said than done, since—given the fact that food processors often change recipes—there’s no list of “safe” foods that never contain MSG. A good start is to avoid anything with MSG anywhere in the ingredient list, but there will still be many foods that have MSG hidden inside other ingredients. Likewise, even products labeled “no MSG added” can still contain these hidden sources.

Best bets for avoiding MSG

• Buy organic produce whenever possible.
• Make things from scratch, avoiding processed ingredients as much as possible.
• Limit making stews or soups in a crock pot, since slow-cooking tends to cause small amounts of glutamic acid to be released from the protein sources (e.g., meat, chicken) in the recipe.

What are your thoughts on MSG? I’d love to hear from you!

Editors Note: To say MSG occurs naturally is missing the point.  It is NOT natural to eat MSG in the quantity that Corporate America is cramming into the food supply.  Nicotine occurs naturally in potatoes, tomatoes, etc.  But you wouldn’t add it to food stuffs.

And there has been a real negative attack on Organic Produce lately. Media all over the world keeps saying it’s not more healthy.  Again missing the point entirely.  While an organic apple may have the same nutrition as a conventionally (Meaning grown with pesticide) apple the Organic apple is free of pesticide.  So the real issue is the pesticide NOT the nutrition.

It’s always about money.  Propaganda and Bullshit coming from the Media being spoon fed by Governments and Corporate interests.

MSG is toxic to the body in any form but naturally occurring.  Avoid it.

Schistosoma mansoni and Schistosoma japonicum both cause the debilitating disease schistomiasis.

The work has already uncovered possible targets for new treatments to combat the disease, which causes symptoms such as fever and fatigue.

The international study features in the journal Nature.

Schistosomiasis cases top 200 million every year, with 20 million people are seriously disabled by severe anaemia, chronic diarrhoea, internal bleeding and organ damage caused by the worms and their eggs, or the immune system reactions they provoke.

In sub-Saharan Africa alone it kills 280,000 people each year.

SCHISTOMIASIS

• People become infected with Schistosoma when they wade or bathe in water inhabited by tiny snails that host the parasites
• The parasites are released into the water, and use fork tails to burrow into the skin
• They travel to blood vessels that supply urinary and intestinal organs, including the liver, where they mature
• Female worms, which live inside the thicker males, release many thousands of eggs each day
• Eggs shed in urine and faeces may make their way into snail-inhabited water, where they hatch to release parasites that seek out snails to begin the cycle again

Dr Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, said: “Chronic infection with Schistosoma parasites makes life miserable for millions of people in tropical countries around the globe, and can lead to death.

“New drugs and other interventions are badly needed to reduce the impact of a disease that lowers quality of life and slows economic development.”

Since the 1980s, a cheap drug, praziquantel has been widely distributed to areas where the disease is common.

However, although the drug is effective, it does not prevent a person becoming re-infected. There is also a risk that the parasites will become resistant to it.

Therefore, developing new drug targets is important.

Enzyme targets

Researchers working on the genetic blueprint of S. masoni, the most widespread of the schistomiasis parasites, found that it was made up of 11,809 genes – about 10 times the size of the malaria parasite genome.

In particular, they identified a large number of genes which produce enzymes that break down proteins, giving the parasite its ability bore through tissue.

Subsequent analysis revealed 120 enzymes that could potentially be targeted with drugs to disrupt the worm’s metabolism.

The researchers also identified 66 drugs already on the market which might also be effective against schistomiasis.

The analysis also found that S. mansoni lacks a key enzyme needed to make essential fats, and must rely on its host to provide these – revealing a potential Achilles’ heel that could be exploited for drug development.

Researcher Dr Matthew Berriman, of the Wellcome Trust Sanger Institute, said: “This genome sequence catapults schistosomiasis research into a new era.

“It provides a foundation for understanding aspects of the parasite’s complex biology as well as a vehicle to immediately identify new targets for drug treatment.”

Fellow researcher Dr Najib El-Sayed, of the University of Maryland, said: “The genome sequence has given us, for the first time, a comprehensive view of the engines that drive the parasite, the strategies that allow it to survive in us, its human host.

“It is a catalogue of opportunities.”

In a separate study, scientists discovered that S. japonicum, which is largely confined to Asia, had even more genes.

Taking a pill to treat depression is widely believed to work by reversing a chemical imbalance.

But in this week’s Scrubbing Up health column, Dr Joanna Moncrieff, of the department of mental health sciences at University College London, says they actually put people into “drug-induced states”.

If you’ve seen a doctor with emotional problems some time over the last 20 years, you may have been told that you had a chemical imbalance, and that you needed tablets to correct it.

It’s not just doctors that think this way, either.

Magazines, newspapers, patient’s organisations and internet sites have all publicised the idea that conditions like depression, anxiety, schizophrenia and bipolar disorder can be treated by drugs that help to rectify an underlying brain problem.

People with schizophrenia and other conditions are frequently told that they need to take psychiatric medication for the rest of their lives to stabilise their brain chemicals, just like a diabetic needs to take insulin.

The trouble is there is little justification for this view of psychiatric drugs.

Altered states

First, although ideas like the serotonin theory of depression have been widely publicised, scientific research has not detected any reliable abnormalities of the serotonin system in people who are depressed.

Second, it is often said that the fact that drug treatment “works” proves that there’s an underlying biological deficiency.

“Psychoactive drugs make people feel different”

But there is another explanation for how psychiatric drugs effect people with emotional problems.

It is frequently overlooked that drugs used in psychiatry are psychoactive drugs, like alcohol and cannabis.

Psychoactive drugs make people feel different, they put people into an altered mental and physical state.

They affect everyone, regardless of whether they have a mental disorder or not.

Therefore, an alternative way of understanding how psychiatric drugs effect people is to look at the psychoactive effects they produce.

Drugs referred to as antipsychotics, for example, dampen down thoughts and emotions, which may be helpful in someone with psychosis.

Drugs like Valium produce a state of relaxation and a pleasant drowsiness, which may reduce anxiety and agitation.

Drugs labelled as “antidepressants” come from many different chemical classes and produce a variety of effects.

Prior to the 1950s, the drugs that were used for mental health problems were thought of as psychoactive drugs, which produced mainly sedative effects.

‘Informed choice’

Views about psychiatric drugs changed over the course of the 1950s and 1960s.

They gradually came to be seen as being specific treatments for specific diseases, or “magic bullets”, and their psychoactive effects were forgotten.

However, this transformation was not based on any compelling evidence.

In my view it remains more plausible that they “work” by producing drug-induced states which suppress or mask emotional problems.

“If we gave people a clearer picture drug treatment might not always be so appealing”

This doesn’t mean psychiatric drugs can’t be useful, sometimes.

But, people need to be aware of what they do and the sorts of effects they produce.

At the moment people are being encouraged to believe that taking a pill will make them feel better by reversing some defective brain process.

That sounds good. If your brain is not functioning properly, and a drug can make it work better, then it makes sense to take the pill.

If, on the other hand, we gave people a clearer picture, drug treatment might not always be so appealing.

If you told people that we have no idea what is going on in their brain, but that they could take a drug that would make them feel different and might help to suppress their thoughts and feelings, then many people might chose to avoid taking drugs if they could.

On the other hand, people who are severely disturbed or distressed might welcome these effects, at least for a time.

People need to make up their own minds about whether taking psychoactive drugs is a useful way to manage emotional problems.

To do this responsibly, however, doctors and patients need much more information about the nature of psychiatric drugs and the effects they produce.

Many people concerned about swine flu have turned to NHS Direct for help, but the telephone helpline which is supposed to take the pressure off doctors is now trying to take the pressure off itself.

The service, set up in 1997, has long been a target for criticism from doctors who have attacked what they see as its over-cautiousness.

Designed to take the strain off frontline staff, some claim it has increased workloads in the past by referring the perfectly healthy to out-of-hour doctors or A&E.

But many value its reassurance and advice and have turned to it in droves since swine flu was first reported. On Tuesday it received more than 9,000 calls relating to the virus – the highest yet.

There have been reports of lengthy waits to speak to an advisor – if you get through. Others have simply heard a recorded message.

One of the problems is that hundreds of fundamentally well people are still calling the service with their questions about swine flu, despite there being another telephone number for this purpose.

“We ended up phoning our after hours GP service and were told to bring our toddler in”

Amanda McGregor

Many others have little wrong with them and are offered advice about home care.

NHS Direct itself is now urging people to use other channels for information, notably the website’s symptom checker.

But the swine flu expert at the British Medical Association – the doctors’s union – said the service was still not effectively triaging, and that too many were ending up calling their GPs.

“NHS Direct has a place in the ordinary run of things but it is not tooled up for this job and it is struggling with the volume of calls,” says Dr Peter Holden.

“As a working GP dealing with possible cases of swine flu NHS Direct has made no difference to my work load and has even made it harder, as I am getting a lot of referrals late in the day.”

Not now

Those with children under five are specifically advised not to use the symptom checker on the NHS Direct website and contact the service directly.

“We are prioritising urgent calls so that people most in need are assessed as quickly as possible and urgent calls are being dealt with in less than 20 minutes”

Nick Chapman
Chief Executive of NHS Direct

Amanda McGregor, a mother of a one-year-old, said she decided to ring NHS Direct for advice and reassurance about her son’s high temperature.

“My husband and I couldn’t believe it when we got an answerphone saying they could not take calls because they had such a high volume of people ringing about swine flu. A voice message said information was available online.”

“We ended up phoning our after hours GP service and were told to bring our toddler in. We were then transferred to accident and emergency and prescribed Tamiflu.”

A fever is the most important symptom of swine flu – that is a temperature of 38C (100.4F) or above

There is reportedly little standard seasonal flu at the moment, so the chances are that if you have the above you do indeed have swine flu, experts say.

“Basically go out and buy a thermometer. If you have a temperature and two of the other symptoms you have flu, and should get treatment. If you’re well enough to go to work, you don’t,” says Dr Holden.

Differentiating

On Tuesday NHS Direct received nearly 9,700 swine flu related calls and its chief executive said it was now encouraging people to use other means of obtaining information.

But Nick Chapman, chief executive of NHS Direct, stressed it was not simply referring callers straight on to GPs as some have claimed, and was sorting out the mildly ill from potential cases of swine flu.

“I am extremely aware of the current pressures facing all parts of the NHS, including GPs, and want to reassure people that NHS Direct is doing all it can to help relieve this pressure. We are dealing with a significantly increased number of calls about swine flu, yesterday alone nurses spoke to over 9,500 people who were worried they had swine flu.

“For half of these people we were able to give advice on how they could treat themselves at home, without advising them to contact their GP for further assessment.

“We are prioritising urgent calls so that people most in need are assessed as quickly as possible and urgent calls are being dealt with in less than 20 minutes. If a call back is required for a non-urgent call we will tell callers how long they have to wait when they speak to someone.”